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Tuesday, December 27, 2011
Rheumatoid Arthritis: Research Reports on Rheumatoid Arthritis from University of Amsterdam Provide New Insights
A report, "Silencing the expression of Ras family GTPase homologues decreases inflammation and joint destruction in experimental arthritis," is newly published data in The American Journal of Pathology. According to the authors of recent research published in the The American Journal of Pathology, "Changes in the expression and activation status of Ras proteins are thought to contribute to the pathological phenotype of stromal fibroblast-like synoviocytes (FLS) in rheumatoid arthritis, a prototypical immune-mediated inflammatory disease. Broad inhibition of Ras and related proteins has shown protective effects in animal models of arthritis, but each of the Ras family homologues (ie, H-, K-, and N-Ras) makes distinct contributions to cellular activation."
"We examined the expression of each Ras protein in synovial tissue and FLS obtained from patients with rheumatoid arthritis and other forms of inflammatory arthritis. Each Ras protein was expressed in synovial tissue and cultured FLS. Each homolog was also activated following FLS stimulation with tumor necrosis factor-a or interleukin (IL)-1?. Constitutively active mutants of each Ras protein enhanced IL-1?-induced FLS matrix metalloproteinase-3 production, while only active H-Ras enhanced IL-8 production. Gene silencing demonstrated that each Ras protein contributed to IL-1?-dependent IL-6 production, while H-Ras and N-Ras supported IL-1?-dependent matrix metalloproteinase-3 and IL-8 production, respectively. The overlap in contributions of Ras homologues to FLS activation suggests that broad targeting of Ras GTPases in vivo suppresses global inflammation and joint destruction in arthritis," wrote Launay D. de and colleagues, University of Amsterdam.
The researchers concluded: "Consistent with this, simultaneous silencing of H-Ras, K-Ras, and N-Ras expression significantly reduces inflammation and joint destruction in murine collagen-induced arthritis, while specific targeting of N-Ras alone is less effective in providing clinical benefits."
de and colleagues published their study in The American Journal of Pathology (Silencing the expression of Ras family GTPase homologues decreases inflammation and joint destruction in experimental arthritis. The American Journal of Pathology, 2010;177(6):3010-24).
For additional information, contact D. de Launay, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.
Keywords: City:Amsterdam, Country:Netherlands, Region:Europe, Proteomics, Amino Acids, Joint Diseases, Peptide Hydrolases, Enzymes and Coenzymes, Metalloendopeptidases, Musculoskeletal Diseases.
This article was prepared by NewsRx editors from staff and other reports. Copyright 2011, NewsRx.com.
Source: http://c.moreover.com/click/here.pl?r5663763138
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Mission Impossible 4 Wins Christmas Weekend Box Office
The mission, should Tom Cruise and company have chosen to accept it, was to come out on top this weekend at the box office, despite the presence of a certain damaged girl with a certain well-known tattoo.
And Mission Impossible: Ghost Protocol - one of Cruise's best-ever reviewed films - accomplished this goal with ease, earning $26.5 million on Friday and Saturday.
The action flick beat out Sherlock Holmes and a disappointing Girl With the Dragon Tattoo, which debuted at number four with $13 million. Here is a look at the top 10 box office results:
- Mission: Impossible:Ghost Protocol - $26.5 million
- Sherlock Holmes: A Game of Shadows - $17.8 million
- Alvin and the Chipmunks: Chipwrecked - $13.3 million
- The Girl with the Dragon Tattoo - $13 million
- The Adventures of Tintin - $9.1 million
- We Bought a Zoo - $7.8 million
- New Year's Eve - $3.0 million
- Arthur Christmas - $2.7 million
- The Twilight Saga: Breaking Dawn Part 1 - $2.1 million
- Hugo - $2.0 million
Source: http://www.thehollywoodgossip.com/2011/12/mission-impossible-4-wins-christmas-weekend-box-office/
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Monday, December 26, 2011
PhilSchwarzmann: Sony Bravia's new slogan: "You'll never stop watching our TV's, your fat ass will get grafted to the couch."
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Sony Bravia's new slogan: "You'll never stop watching our TV's, your fat ass will get grafted to the couch." 
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Source: http://twitter.com/PhilSchwarzmann/statuses/151007462030446592
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Apple Files Patents for Fuel Cell Computers (NewsFactor)
A laptop powered by a hydrogen fuel cell, going for weeks without refueling. That vision of the future is described in a pair of patent applications filed by Apple and made public Thursday.
One of the patent applications, entitled Fuel Cell System to Power a Portable Computing Device, describes a fuel cell system with a fuel cell stack that generates electricity, as well as a system controller and a bidirectional communication link between the controller and the device.
'Days or Even Weeks'
The other application, Fuel Cell System Coupled to a Portable Computing Device, describes a fuel cell system that "is capable of both providing power to and receiving power from a rechargeable battery in a portable computing device." The application notes that this would eliminate "the need for a bulky and heavy battery within the fuel cell system," thus significantly reducing the size, weight, and cost of the fuel cell.
Fuel cells, such as hydrogen fuel cells, can pack a lot of electricity-generating power into a small package. As one of the applications noted, "Fuel cells and associated fuels can potentially achieve high volumetric and gravimetric energy densities," which could potentially mean that portable devices could operate for "days or even weeks without refueling." Similarly, the other application's description of linking the fuel cell to the rechargeable battery helps to keep size and weight down, and time between refueling up.
Apple's applications discuss using sodium borohydride powder mixed with water as a fuel, and the hydrogen would be obtained from the sodium borohydride. The hydrogen then mixes with oxygen via a membrane, producing electricity and water vapor.
'Future Proofing'
The integration of the fuel cell system into the device would assumedly be one of the key features for which patent protection is sought. Another patent application by Apple, published in October, described a design for fuel cell plates.
Laura DiDio, an analyst with Information Technology Intelligence Corp., said Apple's patents indicated it was "future proofing and hedging its bets," and that the real question was whether the innovative company "has something cooking like this in the back room?"
She added that it was possible that Apple is not moving forward on this front, but simply looking to protect itself against other companies' ventures into fuel-cell powered mobile computing devices. Even if the Cupertino, Calif.-based company is using some of its large supply of cash to conduct R&D in this area, DiDio said, it was unlikely that mainstream products would emerge in the next decade or so.
As with many large technology companies, patents figure prominently in Apple's strategy. The biggest example of the importance of patents is the ongoing legal war by Apple with Samsung, HTC, and Motorola Mobility, over aspects of those companies' Android-based devices that Apple says violate its patents. Apple recently won a minor victory in its U.S. patent fight with HTC, lost a next step in its war with Samsung in Australia, and both won and lost some battles with Samsung in Europe.
Source: http://us.rd.yahoo.com/dailynews/rss/environment/*http%3A//news.yahoo.com/s/nf/20111224/bs_nf/81511
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